Polycystic Ovarian Syndrome

Polycystic Ovaries

Polycystic Ovarian Syndrome (PCOS) is a hormonal condition commonly involving high levels of insulin or testosterone. The cause of PCOS is unclear. It is often associated with problems such as irregular periods, excessive hair growth, acne, obesity, infertility and the possible development of diabetes and osteoporosis.

Symptoms

Women with PCOS may experience:

• Irregular menstrual cycles
• Cessation of menstruation
• Weight gain and obesity
• Excessive hair growth, especially on the face and chest
• Acne
• Infertility
• Long term health risks including diabetes and osteoporosis

Treatment and Diagnosis

PCOS is usually diagnosed based on your medical history, a physical examination, ultrasound and blood tests. If you notice any symptoms, make sure you see a doctor. Early diagnosis is important to manage your condition effectively and prevent long-term health problems.

PCOS management can include:

• Lifestyle changes
• Weight loss
• Hormone medications
• Oral contraceptive pill
• Infertility medications

The treatment for PCOS will depend on the symptoms. It's important to use a broad approach to manage PCOS. If only one or two symptoms are addressed on a short-term basis, a woman may be left with long-term clinical problems.

Dr Omar Gailani can advise about what treatment best suits you.

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder and one of the common causes of infertility among women. 

It is characterized by an ovulation dysfunction or impedance to the normal growth and release of eggs from the ovaries. It is commonly seen in women of childbearing age and is rare after menopause.

The hormonal imbalance results in enlarged ovaries containing several small cysts (fluid-filled sacs).

Causes of Polycystic ovarian syndrome (PCOS)

The exact cause of polycystic ovarian syndrome is unknown. However, several factors including genetics and lifestyle have been implicated to play a role in the development of PCOS.

Women with a family history of polycystic ovarian syndrome are at a higher risk of developing this condition.

Researchers have also found an association between excessive insulin production and development of PCOS. Insulin hormone regulates blood sugar levels and any disorder affecting the insulin mechanism may result in excessive insulin secretion, which triggers androgen secretion from the ovaries.

Low grade inflammation, in response to ingestion of certain foods, may lead to the release of substances that can cause insulin resistance and cholesterol accumulation in the blood vessels or atherosclerosis.

Clinical studies have demonstrated the presence of low grade inflammation in women with PCOS. Excessive exposure to the male hormone during the fetal period may disrupt the function of normal genes and increase the risk of insulin resistance and low grade inflammation.

Symptoms of Polycystic ovarian syndrome (PCOS)

The symptoms of polycystic ovarian syndrome vary from person to person and depend upon the nature and severity of the condition.

Some of the symptoms of PCOS include

• Infertility
• Absent or irregular menstrual cycle, and
• Obesity or accumulation of fat usually around the waist
• Abnormal facial and body hair
• Adult acne
• Male pattern baldness or hair thinning may develop due to excessive androgen secretion

In some patients black or dark brown patches are seen around the skin of the neck, arm, breasts or thighs. Patients can experience anxiety or depression and breathlessness during sleep.

Diagnosis of Polycystic ovarian syndrome (PCOS)

The diagnosis of polycystic ovarian syndrome is based on the medical history along with a physical and pelvic examination to evaluate the condition of the patient and help identify the underlying cause.

Test conducted could include:

• Blood tests are conducted to determine the level of various hormones
• Glucose tolerance test and
• Evaluation of blood cholesterol may also be conducted
• Pelvic ultrasound is performed to evaluate the appearance of the ovaries and the uterine lining

Treatments for Polycystic ovarian syndrome (PCOS)

The treatment of polycystic ovarian syndrome is based on the symptoms and individual concerns such as infertility, irregular menstrual cycle, acne or obesity.

Both medications and surgical treatment can be used for the management of PCOS. Infertility may be treated by fertility therapy with ovulation-inducing drugs.

• Pelvic Ultrasound

Drug Therapy

Clomiphene citrate, an oral anti-estrogen, may be prescribed to patients. In some patients, Dr Gailani may add metformin to clomiphene to help induce ovulation. In patients not responding to clomiphene and metformin, gonadotropins, namely, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) can be administered by injection.

Oral contraceptives

Oral contraceptives may be prescribed for the management of irregular menstrual cycles. Oral contraceptives effectively reduce the level of male hormone and are also effective in reducing excessive body hair growth and also minimize the risks of uterine cancer.

Lifestyle modifications

Lifestyle modifications and anti-diabetic medications may be prescribed for the management or prevention of obesity and diabetes mellitus.

Surgery

Surgery may be recommended in patients who do not respond to medications. Laparoscopic ovarian drilling, a surgical procedure, may be used to treat the condition and induce ovulation. This has been rarely associated with ovarian adhesions and infertility.

PCOS and other associated conditions

Patients with polycystic ovarian syndrome frequently develop other serious medical conditions such as

• Diabetes mellitus
• Cardiovascular diseases
• Pregnancy induced high blood pressure
• Miscarriage or premature delivery

These patients are also at risk of uterine cancer, anxiety or depression.